Emergence, Epidemiology, and Transmission Dynamics of 2009 Pandemic A/H1N1 Influenza in Kampala, Uganda, 2009–2015
Identifieur interne : 000323 ( Main/Exploration ); précédent : 000322; suivant : 000324Emergence, Epidemiology, and Transmission Dynamics of 2009 Pandemic A/H1N1 Influenza in Kampala, Uganda, 2009–2015
Auteurs : Matthew J. Cummings [États-Unis] ; Barnabas Bakamutumaho [Ouganda] ; Wan Yang [États-Unis] ; Joseph F. Wamala [Ouganda, Soudan du Sud] ; John Kayiwa [Ouganda] ; Nicholas Owor [Ouganda] ; Barbara Namagambo [Ouganda] ; Timothy Byaruhanga [Ouganda] ; Allison Wolf [États-Unis] ; Julius J. Lutwama [Ouganda] ; Jeffrey Shaman [États-Unis] ; Max R. O Onnell [États-Unis]Source :
- The American Journal of Tropical Medicine and Hygiene [ 0002-9637 ] ; 2017.
Abstract
In sub-Saharan Africa, little is known about the epidemiology of pandemic-prone influenza viruses in urban settings. Using data from a prospective sentinel surveillance network, we characterized the emergence, epidemiology, and transmission dynamics of 2009 pandemic A/H1N1 influenza (H1N1pdm09) in Kampala, Uganda. After virus introduction via international air travel from England in June 2009, we estimated the basic reproductive number in Kampala to be 1.06–1.13, corresponding to attack rates of 12–22%. We subsequently identified 613 cases of influenza in Kampala from 2009 to 2015, of which 191 (31.2%) were infected with H1N1pdm09. Patients infected with H1N1pdm09 were more likely to be older adult (ages 35–64) males with illness onset during rainy season months. Urban settings in sub-Saharan Africa are vulnerable to importation and intense transmission of pandemic-prone influenza viruses. Enhanced surveillance and influenza pandemic preparedness in these settings is needed.
Url:
DOI: 10.4269/ajtmh.17-0524
PubMed: 29141723
PubMed Central: 5928728
Affiliations:
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Cummings</name><affiliation wicri:level="2"><nlm:aff id="aff1">Division of Pulmonary, Allergy, and Critical Care Medicine, Columbia University Medical Center, New York;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Division of Pulmonary, Allergy, and Critical Care Medicine, Columbia University Medical Center</wicri:cityArea></affiliation></author><author><name sortKey="Bakamutumaho, Barnabas" sort="Bakamutumaho, Barnabas" uniqKey="Bakamutumaho B" first="Barnabas" last="Bakamutumaho">Barnabas Bakamutumaho</name><affiliation wicri:level="1"><nlm:aff id="aff2">National Influenza Center, Uganda Virus Research Institute, Entebbe, Uganda;</nlm:aff><country xml:lang="fr">Ouganda</country><wicri:regionArea>National Influenza Center, Uganda Virus Research Institute, Entebbe</wicri:regionArea><wicri:noRegion>Entebbe</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Wan" sort="Yang, Wan" uniqKey="Yang W" first="Wan" last="Yang">Wan Yang</name><affiliation wicri:level="2"><nlm:aff id="aff3">Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York</wicri:cityArea></affiliation></author><author><name sortKey="Wamala, Joseph F" sort="Wamala, Joseph F" uniqKey="Wamala J" first="Joseph F." last="Wamala">Joseph F. Wamala</name><affiliation wicri:level="1"><nlm:aff id="aff4">Epidemiology and Surveillance Division, Ministry of Health, Kampala, Uganda;</nlm:aff><country xml:lang="fr">Ouganda</country><wicri:regionArea>Epidemiology and Surveillance Division, Ministry of Health, Kampala</wicri:regionArea><wicri:noRegion>Kampala</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5">South Sudan Country Office, World Health Organization, Juba, South Sudan;</nlm:aff><country xml:lang="fr">Soudan du Sud</country><wicri:regionArea>South Sudan Country Office, World Health Organization, Juba</wicri:regionArea><wicri:noRegion>Juba</wicri:noRegion></affiliation></author><author><name sortKey="Kayiwa, John" sort="Kayiwa, John" uniqKey="Kayiwa J" first="John" last="Kayiwa">John Kayiwa</name><affiliation wicri:level="1"><nlm:aff id="aff2">National Influenza Center, Uganda Virus Research Institute, Entebbe, Uganda;</nlm:aff><country xml:lang="fr">Ouganda</country><wicri:regionArea>National Influenza Center, Uganda Virus Research Institute, Entebbe</wicri:regionArea><wicri:noRegion>Entebbe</wicri:noRegion></affiliation></author><author><name sortKey="Owor, Nicholas" sort="Owor, Nicholas" uniqKey="Owor N" first="Nicholas" last="Owor">Nicholas Owor</name><affiliation wicri:level="1"><nlm:aff id="aff2">National Influenza Center, Uganda Virus Research Institute, Entebbe, Uganda;</nlm:aff><country xml:lang="fr">Ouganda</country><wicri:regionArea>National Influenza Center, Uganda Virus Research Institute, Entebbe</wicri:regionArea><wicri:noRegion>Entebbe</wicri:noRegion></affiliation></author><author><name sortKey="Namagambo, Barbara" sort="Namagambo, Barbara" uniqKey="Namagambo B" first="Barbara" last="Namagambo">Barbara Namagambo</name><affiliation wicri:level="1"><nlm:aff id="aff2">National Influenza Center, Uganda Virus Research Institute, Entebbe, Uganda;</nlm:aff><country xml:lang="fr">Ouganda</country><wicri:regionArea>National Influenza Center, Uganda Virus Research Institute, Entebbe</wicri:regionArea><wicri:noRegion>Entebbe</wicri:noRegion></affiliation></author><author><name sortKey="Byaruhanga, Timothy" sort="Byaruhanga, Timothy" uniqKey="Byaruhanga T" first="Timothy" last="Byaruhanga">Timothy Byaruhanga</name><affiliation wicri:level="1"><nlm:aff id="aff2">National Influenza Center, Uganda Virus Research Institute, Entebbe, Uganda;</nlm:aff><country xml:lang="fr">Ouganda</country><wicri:regionArea>National Influenza Center, Uganda Virus Research Institute, Entebbe</wicri:regionArea><wicri:noRegion>Entebbe</wicri:noRegion></affiliation></author><author><name sortKey="Wolf, Allison" sort="Wolf, Allison" uniqKey="Wolf A" first="Allison" last="Wolf">Allison Wolf</name><affiliation wicri:level="2"><nlm:aff id="aff1">Division of Pulmonary, Allergy, and Critical Care Medicine, Columbia University Medical Center, New York;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Division of Pulmonary, Allergy, and Critical Care Medicine, Columbia University Medical Center</wicri:cityArea></affiliation></author><author><name sortKey="Lutwama, Julius J" sort="Lutwama, Julius J" uniqKey="Lutwama J" first="Julius J." last="Lutwama">Julius J. Lutwama</name><affiliation wicri:level="1"><nlm:aff id="aff2">National Influenza Center, Uganda Virus Research Institute, Entebbe, Uganda;</nlm:aff><country xml:lang="fr">Ouganda</country><wicri:regionArea>National Influenza Center, Uganda Virus Research Institute, Entebbe</wicri:regionArea><wicri:noRegion>Entebbe</wicri:noRegion></affiliation></author><author><name sortKey="Shaman, Jeffrey" sort="Shaman, Jeffrey" uniqKey="Shaman J" first="Jeffrey" last="Shaman">Jeffrey Shaman</name><affiliation wicri:level="2"><nlm:aff id="aff3">Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York</wicri:cityArea></affiliation></author><author><name sortKey="O Onnell, Max R" sort="O Onnell, Max R" uniqKey="O Onnell M" first="Max R." last="O Onnell">Max R. O Onnell</name><affiliation wicri:level="2"><nlm:aff id="aff1">Division of Pulmonary, Allergy, and Critical Care Medicine, Columbia University Medical Center, New York;</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Division of Pulmonary, Allergy, and Critical Care Medicine, Columbia University Medical Center</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="aff6">Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Epidemiology, Mailman School of Public Health, Columbia University, New York</wicri:cityArea></affiliation></author></analytic><series><title level="j">The American Journal of Tropical Medicine and Hygiene</title><idno type="ISSN">0002-9637</idno><idno type="eISSN">1476-1645</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract.</title><p>In sub-Saharan Africa, little is known about the epidemiology of pandemic-prone influenza viruses in urban settings. Using data from a prospective sentinel surveillance network, we characterized the emergence, epidemiology, and transmission dynamics of 2009 pandemic A/H1N1 influenza (H1N1pdm09) in Kampala, Uganda. After virus introduction via international air travel from England in June 2009, we estimated the basic reproductive number in Kampala to be 1.06–1.13, corresponding to attack rates of 12–22%. We subsequently identified 613 cases of influenza in Kampala from 2009 to 2015, of which 191 (31.2%) were infected with H1N1pdm09. Patients infected with H1N1pdm09 were more likely to be older adult (ages 35–64) males with illness onset during rainy season months. Urban settings in sub-Saharan Africa are vulnerable to importation and intense transmission of pandemic-prone influenza viruses. Enhanced surveillance and influenza pandemic preparedness in these settings is needed.</p></div></front></TEI><affiliations><list><country><li>Ouganda</li><li>Soudan du Sud</li><li>États-Unis</li></country><region><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Cummings, Matthew J" sort="Cummings, Matthew J" uniqKey="Cummings M" first="Matthew J." last="Cummings">Matthew J. Cummings</name></region><name sortKey="O Onnell, Max R" sort="O Onnell, Max R" uniqKey="O Onnell M" first="Max R." last="O Onnell">Max R. O Onnell</name><name sortKey="O Onnell, Max R" sort="O Onnell, Max R" uniqKey="O Onnell M" first="Max R." last="O Onnell">Max R. O Onnell</name><name sortKey="Shaman, Jeffrey" sort="Shaman, Jeffrey" uniqKey="Shaman J" first="Jeffrey" last="Shaman">Jeffrey Shaman</name><name sortKey="Wolf, Allison" sort="Wolf, Allison" uniqKey="Wolf A" first="Allison" last="Wolf">Allison Wolf</name><name sortKey="Yang, Wan" sort="Yang, Wan" uniqKey="Yang W" first="Wan" last="Yang">Wan Yang</name></country><country name="Ouganda"><noRegion><name sortKey="Bakamutumaho, Barnabas" sort="Bakamutumaho, Barnabas" uniqKey="Bakamutumaho B" first="Barnabas" last="Bakamutumaho">Barnabas Bakamutumaho</name></noRegion><name sortKey="Byaruhanga, Timothy" sort="Byaruhanga, Timothy" uniqKey="Byaruhanga T" first="Timothy" last="Byaruhanga">Timothy Byaruhanga</name><name sortKey="Kayiwa, John" sort="Kayiwa, John" uniqKey="Kayiwa J" first="John" last="Kayiwa">John Kayiwa</name><name sortKey="Lutwama, Julius J" sort="Lutwama, Julius J" uniqKey="Lutwama J" first="Julius J." last="Lutwama">Julius J. Lutwama</name><name sortKey="Namagambo, Barbara" sort="Namagambo, Barbara" uniqKey="Namagambo B" first="Barbara" last="Namagambo">Barbara Namagambo</name><name sortKey="Owor, Nicholas" sort="Owor, Nicholas" uniqKey="Owor N" first="Nicholas" last="Owor">Nicholas Owor</name><name sortKey="Wamala, Joseph F" sort="Wamala, Joseph F" uniqKey="Wamala J" first="Joseph F." last="Wamala">Joseph F. Wamala</name></country><country name="Soudan du Sud"><noRegion><name sortKey="Wamala, Joseph F" sort="Wamala, Joseph F" uniqKey="Wamala J" first="Joseph F." last="Wamala">Joseph F. Wamala</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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